ResultĪll of the patients had positive assay results for cerebral spinal fluid (CSF) Treponema pallidum hemagglutination (TPHA). The demographic and clinical manifestations, laboratory tests, and neuroimaging and neuropsychological characteristics were analysed in 55 general paresis patients with psychiatric disorders, including 29 patients misdiagnosed as primary psychiatric disease and 26 patients diagnosed as having general paresis after being seen once by a doctor. The results may assist clinicians in the early identification of neurosyphilis with a mental disorder. The purpose of this study was to explore the differences in the clinical and neuropsychological characteristics of general paresis between patients misdiagnosed as having a primary psychiatric disease and patients diagnosed correctly upon seeing a doctor. Patients with a psychiatric manifestation are often misdiagnosed. Psychiatric disorders as a cause of general paresis have become more common due to the use of antibiotics. In addition, the manifestations of neurosyphilis are not typical. Neurosyphilis is the “great imitator” because it can mimic many types of medical disorders. The main manifestation of general paresis is dementia however, this is different from the other types of dementia, which can be cured by adequate doses of penicillin in the early stage. General paresis (GP) is a type of neurosyphilis. Neurosyphilis is caused by the invasion of Treponema pallidum into the central nervous system.
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